The biology of cancer stem cells (CSC's)

A central question in cancer biology is, which cells can be transformed to form tumors? Recent studies elucidated the presence of cancer stem cells (CSC's) that have the exclusive ability to regenerate tumors.
These (CSC's) share many characteristics with normal stem cells, including self-renewal and differentiation. With the growing evidence that cancer stem cells exist in a wide array of tumors. It is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth.

This new paradigm of ontogenesis has been validated in a growing list of tumors. Studies of normal and cancer stem cells from the same tissue have shed light on the ontogeny of tumors. That signaling pathways such as Bmi1 and Wnt have similar effects in normal cells and cancer stem cells. Self-renewal suggests that common molecular pathways regulate both populations. 

Understanding the biology of cancer stem cells will contribute to the identification of molecular targets important for future therapies. The actual approach I'm advocating is to bring remaining CSC's after chemotherapy or radiation in a "knock-out" status with a cocktail of compounds that we have studied for more than 2 years. Herewith I address my request to collaborate with me in this topic. 

Prof. Guy van Elsacker Dr.Sc. 
Biomed Expert
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